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Bratislava Medical Journal Vol.113, No.10, p.583–588, 2012 |
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Title: Effect of streptozotocin induced diabetes on rat hippocampus | ||
Author: N. Pamidi, B. N. Satheesha-Nayak | ||
Abstract: Objective: The present study was designed to evaluate the diabetes induced neuronal damage in the hippocampus of the rat brain. The rats were divided into (A) Normal Control (B) Vehicle Control (C) 15 days of Streptozotocin (STZ), (D) 30 days of STZ, (E) 45 days of STZ, (F) 60 days of STZ diabetic groups (n = 6 in each group). Blood glucose levels and body weight were measured before STZ injection, 2 days after STZ injection and on the day of sacrifice. At the end of the experimental period rats were scarified and brains were processed for cresyl violet staining and the number of survived neurons in the hippocampus was quantified. |
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Keywords: streptozotocin, diabetes, hippocampus, neurons. | ||
Year: 2012, Volume: 113, Issue: 10 | Page From: 583, Page To: 588 | |
doi:10.4149/BLL_2012_130 |
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