Home Bratislava Medical Journal 2012 Bratislava Medical Journal Vol.113, No.10, p.589–591, 2012

Journal info


Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


Aims and Scope
Editorial Info
Submission Guidelines

Select Journal

Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Bratislava Medical Journal Vol.113, No.10, p.589–591, 2012

Title: Impact of nitric oxide precursor L-arginine on oxidative stress against typhoid
Author: S. S. Haque

Abstract: Objectives: Typhoid fever is a global health problem caused by Salmonella. Salmonellae are gram-negative, flagellate, nonsporulating, facultative anaerobic bacilli that ferment glucose, reduce nitrate to nitrite, and synthesize peritrichous flagella when motile. Nowadays, most of the drugs are resistant, the fact of which compels the search for formulated drugs. Nitric oxide (NO) and its congeners react with different compounds or radicals probably mediating the broad-spectrum antimicrobial activity of reactive nitrogen species (RNS) as well as reactive oxygen species (ROS) against diverse microorganisms. Exogenous administration of L-arginine results in increased NO production. The formulation of NO precursors, (i.e. of L -arginine and ciprofloxacin) is used against experimentally induced salmonellosis. Lipid hydroperoxide can be decomposed to produce alkoxy and peroxy radicals which eventually yield numerous carbonyl products such as malondialdehyde (MDA).
Material and methods: Estimation of lipid peroxidation (LPO) was done by modified method of Utley et al (1967).
Results and discussion: Infection with S. typhimurium significantly induced lipid peroxidation on days 8 and 11 as indicated by enhancement of MDA levels compared to the control mice (20 % and 9.52 %) (Tab. 1, Fig. 2, Ref. 20). 

Keywords: nitric oxide, lipid peroxidation.
Year: 2012, Volume: 113, Issue: 10 Page From: 589, Page To: 591

download file

© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.