Bratislava Medical Journal Vol.113, No.10, p.612–615, 2012
|Title: Ischemia-modified albumin (IMA) in differential diagnosis of transient myocardial ischemia from non ischemic chest pain|
|Author: S. Sokhanvar, A. O. Mellati, S. N. Mousavinasab, L. Taran, B. Vahdani, Z. Golmmohamadi|
Background: Early diagnosis of acute coronary syndrome (ACS) is an important factor in reducing mortality of this disease. Cardiac troponins are not elevated within first hours. So there is a need to optimize the clinical applicability and accuracy of novel ACS markers, particularly with regard to utilizing this technique in combination with other diagnostic methods.
Results: In this study median IMA values were definitely higher in patients with ACS compared with non ischemic chest pain (NICP) (p < 0.0001) (83.5 to 49.6).
An IMA cut-off threshold derived from the receiver operating characteristics curve (ROC) was 85U/ml and gives 54 % (95%CI 51 to 56) sensitivity and 87 % (95%CI 83 to 92) specificity in our population. Negative predictive value was 62 % (95%CI 59 to 66). When IMA and ECG and cTnT were considered together sensitivity was 97.5 % and specificity was 63 %, respectively.
|Keywords: ischemia modified albumin, acute coronary syndrome, unstable angina.|
|Year: 2012, Volume: 113, Issue: 10||Page From: 612, Page To: 615|