Home General Physiology and Biophysics 2012 General Physiology and Biophysics Vol.31, No.4, p.357–366, 2012

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

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General Physiology and Biophysics Vol.31, No.4, p.357–366, 2012

Title: Molecular biology of toll-like receptors
Author: Zoltan Szatmary

Abstract: Toll-like receptors (TLRs) play important roles in host resistance to infections, but also act as mediators of pathologies in autoimmunity, septic shock, metabolic disease and cancer. TLRs are expressed in sentinel cells of the immune system (most notably dendritic cells and macrophages) and are key sensors of bacteria, viruses, fungi and protozoa (O’Neill 2006). TLRs also recognize endogenous ligands present in tissues and cells in the absence of infection (Kawai and Akira 2005; Nizet 2006; Kim et al. 2009). In this review, the TLRs are characterized at the cellular level with emphasis on TLR-mediated signaling pathways along with their negative regulation, including specificity of the response(s) at the promoter level.

Keywords: Toll-like receptor — Adaptor — Signal transduction — Inflammation — Anti-viral response
Year: 2012, Volume: 31, Issue: 4 Page From: 357, Page To: 366

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