Home General Physiology and Biophysics 2012 General Physiology and Biophysics Vol.31, No.4, p.375–382, 2012

Journal info


Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
6 times per year

Aims and Scope
Editorial Info
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

General Physiology and Biophysics Vol.31, No.4, p.375–382, 2012

Title: Calcium transporters and their role in the development of neuronal disease and neuronal damage
Author: Katarina Jaskova, Michaela Pavlovicova, Dana Jurkovicova
Abstract: Neurodegeneration comprises assembly of pathophysiological events that gives rise to a progressive loss of neuronal structure and function including cellular damage, diseases development or cellular death. Neurons respond by adjusting signaling pathways, from gene expression to morphological changes. In most of these processes, Ca2+ signaling plays a pivotal role. By increasing the Ca2+ concentration, the cell responds to neuronal, neurotrophic and other growth factor stimuli, however, the molecular mechanism of Ca2+-dependent neurite outgrowth and development yet requires further elucidation.
Here we focus on the role of Ca2+ and selected Ca2+ transporters involved in processes of CNS neurodegeneration – inositol 1,4,5-trisphosphate (IP3Rs) and ryanodine receptors (RyRs), considering the fact that these receptors may be important “sensors” of disturbed intracellular calcium homeostasis. We propose that in vitro cellular models could serve as suitable experimental systems for the determination of the role that these receptors play in neuropathological conditions.
Recognition of the principles, key players and regulatory processes may elucidate the role of Ca2+ in the regulation of neuronal proliferation, development and differentiation, growth and axon navigation in neurodegenerative and regenerative processes. This may provide a new insight and also discovery of novel therapeutic-targeting possibilities for severe neurological disorders and pathophysiological changes.
Keywords: Neuronal diseases — Neuronal injury — Neurodegeneration — Intracellular Ca2+ transporters — In vitro cellular model
Year: 2012, Volume: 31, Issue: 4 Page From: 375, Page To: 382
doi:10.4149/gpb_2012_053


download file


© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.