General Physiology and Biophysics Vol.31, No.4, p.469

General Physiology and Biophysics Vol.31, No.4, p.469–474, 2012

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
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General Physiology and Biophysics Vol.31, No.4, p.469–474, 2012
Title: Increased ubiquinone concentration after intracerebroventricularly-administered ubiquinol to selected rat brain regions
Author: Anna Gvozdjáková, Boris Mravec, Jarmila Kucharská, Lubica Lackovičová, Katarína Ondičová, Martin Tkačov, Ram B. Singh

Abstract: Brain coenzyme Q10 (CoQ10) concentration can influence the activity of several brain regions, including those which participate in the regulation of cardiovascular circadian rhythms, food intake, neuroendocrine stress response, activity and sleep regulation. However, the effect of supplemented ubiquinol (reduced CoQ) into brain regions is not known. This study determined baseline levels of ubiquinone (oxidized CoQ) in various rat brain regions and proved the bioavailability of the liposomal ubiquinol to selected brain regions after its administration into right brain ventricle. Our data indicate that administration of ubiquinol may create the basis for modulation of neuronal activities in specific brain regions.

Keywords: Ubiquinol — Ubiquinone — Brain regions

Year: 2012, Volume: 31, Issue: 4	Page From: 469, Page To: 473
doi:10.4149/gpb_2012_052
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