Home General Physiology and Biophysics 2012 General Physiology and Biophysics Vol.31, No.4, p.473–478, 2012

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.31, No.4, p.473–478, 2012

Title: NGF-induced neurite outgrowth in PC12 cells is independent of calcium entry through L-type calcium channels
Author: Lucia Lichvárová, Katarína Jašková, Ľubica Lacinová

Abstract: Neuronal growth factor (NGF) induces neurodifferentiation of PC12 cells into cholinergic neurons-like cells. It was shown that intracellular Ca2+ ions participate in regulation of the differentiation of PC12 cells. We tested whether L-type calcium channels contribute to Ca2+ entry which supports neurite outgrowth accompanying NGF-activated differentiation process. Development of morphological changes did correlate with increase of functional expression of L-type calcium channels. However, inhibition of L-type calcium channels by 1 μM of isradipine did not affect significantly an NGF-activated neurite outgrowth.

Keywords: PC12 cells — L-type calcium channels — Dihydropyridines — Neurite outgrowth
Year: 2012, Volume: 31, Issue: 4 Page From: 473, Page To: 478

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