Home Bratislava Medical Journal 2012 Bratislava Medical Journal Vol.113, No.12, p.692–697, 2012

Journal info


 


Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

Aims and Scope
Editorial Info
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Bratislava Medical Journal Vol.113, No.12, p.692–697, 2012

Title: Effects of diosmine-hesperidine on experimental colonic anastomosis
Author: A. Cengiz, S. Tabak, S. Kuru, A. H. Demirel, A. M. Barlas, T. Altun, M. Gonultas, S. Celepli, S. S. Kilicoglu, A. Aydogan, B. Kilicoglu

Abstract:

Aim: Our goal was to determine the effects of a diosmine-hesperidine combination on wound healing in a rat model of colonic anastomosis.
Materials and methods: In this study, 20 Wistar Albino female rats were randomized into four experimental groups containing five rats in each group. A segment of 1 cm of colon was excised 4 cm proximally to the peritoneal reflection in all rats without carrying out any mechanical or antibacterial bowel preparation. Colonic anastomosis was performed with interrupted, inverting sutures of 6/0 polypropylene. Beginning from the first postoperative day, the rats in Groups II and IV received 100 mg/kg per day of diosmine-hesperidine via orogastic route by 4F fine feeding catheter.

Results: A significant difference was detected between groups in terms of their hydroxyproline levels (p<0.05); the hydroxyproline level of Group I was significantly lower than that of the other groups while no significant difference was noted between Groups II and III.


Conclusion: The administration of diosmine-hesperidine increased the amount of collagen and bursting pressures at the anastomotic site and thus had favorable influences on the healing of colonic anastomosis (Tab. 1, Fig. 3, Ref. 33).



Keywords: diosmine-hesperidine, colonic anastomosis.
Year: 2012, Volume: 113, Issue: 12 Page From: 692, Page To: 697
doi:10.4149/BLL_2012_157
Price: 14.40 €






© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.