Home CONTACT Neoplasma 2013 Neoplasma Vol.60, No.2, p.143-150, 2013

Journal info

6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

Editorial Info
Abstracted and Indexed
Submission Guidelines

Select Journal

Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Neoplasma Vol.60, No.2, p.143-150, 2013

Title: Pathological implication and function of Bcl2-inhibitor of transcription in ovarian serous papillary adenocarcinomas
Author: W. HUA, S. MIAO, W. ZOU, H. YANG, B. L. CHEN

Abstract: The Bit-1 protein appears to be a part of the integrin-specific signaling pathway involved into anoikis. When Bit1 is released from the mitochondria into the cytoplasm it can elicit caspase-independent apoptosis. The expression of Bit1 in 78 serous papillary adenocarcinomas and 78 normal epithelial ovarian tissue specimens was analyzed by immunohistochemistry. We also investigate Bit1 function by transfection. Bit1 was expressed in 100% and 33.3% of ovarian cancers and normal epithelial tissues, respectively, and its expression was significantly correlated with histologic grade and overall survival. However, Bit1 expression was not associated with age. We also confirmed that Bit1 overexpression in cytosol of Caov-3 cells induced apoptosis. Bit1 may be a useful pathological marker and a prognostic marker for serous papillary adenocarcinomas outcome. Its pro-apoptotic property also makes it a potential gene medicine for ovarian cancers therapy.

Keywords: Bit1 (Bcl2-inhibitor of transcription), serous papillary adenocarcinomas, Apoptosis, Anoikis
Published online: 26-Nov-2012
Year: 2013, Volume: 60, Issue: 2 Page From: 143, Page To: 150

download file

© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.