Home CONTACT Neoplasma 2013 Neoplasma Vol.60, No.2, p.167-173, 2013

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ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.60, No.2, p.167-173, 2013

Title: Is there still a role for autologous stem cell transplantation in acute myeloid leukemia?

Abstract: the role of autologous stem cell transplantation (ASCT) in treatment of acute myeloid leukemia (AML) remains unsettled. Aims: retrospective analysis to evaluate the role of ASCT in patients with AML without HLA-matched donor. Methods: between December 19, 1994 and August 1, 2012, a total of 63 patients with AML without HLA-matched donor in the department of Hematology and Transfusion Medicine, University Hospital, Bratislava, received an ASCT. Median age was 41 years (20-61 years). There were 35 (56%) males and 28 (44%) females. At the time of ASCT, 50 (79%) patients were in first complete remission (CR), 11 (18%) patients were in second CR and 2 (3%) patients were in relapse. Results: with a median follow-up of 115 months (34-214 months), the 10 year overall survival (OS) and disease free survival (DFS) of all patients was 55% and 51%, respectively. Transplant-related mortality was 6%. The relapse rate was 38% and 9 years probability of relapse was 44%. Conclusion: ASCT is still an effective post-remission treatment in AML patients without HLA-matched donor; with the possibility of long-term survival or even cure in remarkable proportion of patients with AML, particularly in patients with favorable and intermediate cytogenetic risk.

Keywords: acute myeloid leukemia, autologous stem cell transplantation, survival, treatment
Published online: 26-Nov-2012
Year: 2013, Volume: 60, Issue: 2 Page From: 167, Page To: 173

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