Home CONTACT Neoplasma 2013 Neoplasma Vol.60, No.2, p.196-202, 2013

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.60, No.2, p.196-202, 2013

Title: RKIP inhibits the malignant phenotypes of gastric cancer cells
Author: X. M. ZHANG, H. GU, L. YAN, G. Y. ZHANG

Abstract: Raf kinase inhibitor protein (RKIP) is first identified as an interacting partner of Raf-1. RKIP expression is low or absent in several established cell lines derived from metastatic breast cancer, prostate cancer and melanoma cells. However, the functional role of RKIP in gastric cancer remains unclear. In this study, we employed human gastric cancer cell line SGC7901 as a model to reconstitute RKIP expression in gastric cancer cells. The growth curve and soft agar assay showed that RKIP inhibited the growth and clonogenicity of SGC7901 cells. Flow cytometry analysis showed that RKIP inhibited the cell cycle progression and induced the apoptosis of SGC7901 cells. Wound healing and transwell invasion assay showed that RKIP inhibited the migration and invasion of SGC7901 cells. Furthermore, we observed that RKIP inhibited the growth of SMGC7901 cells in xenografts in nude mice. Taken together, our in vitro and in vivo data demonstrate that RKIP modulates the proliferation, apoptosis, migration, invasion and tumorigenicity of SGC7901 cells. These results reveal the tumor suppressor role of RKIP in gastric cancer and suggest that RKIP may be new therapeutic target for gastric cancer.

Keywords: Gastric cancer, RKIP, Raf; tumor suppressor, SGC7901, apoptosis
Published online: 26-Nov-2012
Year: 2013, Volume: 60, Issue: 2 Page From: 196, Page To: 202

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