Home Acta Virologica 2012 Acta Virologica Vol.56, No.4, p.283-291, 2012

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Acta Virologica Vol.56, No.4, p.283-291, 2012

Title: Comparative analysis of the envelope glycoproteins of foamy viruses
Author: YAN SUN, DI-DI WEN, QING-MEI LIU, XIAO-FANG YI, TING-TING WANG, LIN-LAN WEI, ZHI LI, WAN-HONG LIU, XIAO-HUA HE
Abstract: One of the most fascinating findings in retrovirology is the construction of viral vectors based on foamy viruses (FVs) for gene therapy. The envelope glycoprotein (Env), one of the structural proteins of FV, is an important antigen in the immunoassays, as it is highly specific. To compare the characteristics of all 15 available FV Envs, the phylogenesis, hydrophobicity, modifications, and conserved motifs were analyzed based on the Env sequences. Meanwhile, the secondary structures of transmembrane (TM) domains of FV Envs were predicted. The results of phylogenetic analyses based on Envs indicated that the foamy viruses from different hosts could form three groups. The hydrophobicity analysis revealed that FV Envs had two prominent hydrophobic regions, which was similar to other retroviruses. Though the glycosylation, ubiquitination, and the secondary structures of TM domains of FV Envs were in line with other retroviruses, the roles were distinctly different. Interestingly, the analyses of conserved motifs suggested that FV Envs possessed several specific functional motifs.
Keywords: foamy virus; envelope glycoprotein; sequence analysis; phylogenetic analysis
Year: 2012, Volume: 56, Issue: 4 Page From: 283, Page To: 291
doi:10.4149/av_2012_04_283
Price: 18.00 €





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