Home Bratislava Medical Journal 2013 Bratislava Medical Journal Vol.114, No.2, p.93–95, 2013

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.114, No.2, p.93–95, 2013

Title: No association between bronchial asthma and HLA-DRB1, -DQB1 alleles in the Slovak population
Author: M. Dzurilla, M. Vrlík, M. Homolová, M. Buc

Abstract: 109 patients (62 boys/men and 47 girls/women) suffering from bronchial asthma induced by pollen allergens were typed for HLA-DRB1 and -DQBl alleles, respectively, by a low resolution SSP technique. Frequencies of DRB1 alleles varied from 0.5 % to 16.1 %. The most frequent was HLA-DRB1*11 (16.1 %), the least frequent HLA-DRB1*09 (0.4 %). Occurrence rates of HLA-DQB1 alleles ranged from 2.3 % to 37.2 %, HLA-DQB1*03 being the most frequent (37.2 %) and DQB1*04 stood on the opposite pole (2.3 %). By comparing to occurrence rates in the healthy population, no statistically significant differences were disclosed (Tab. 2, Ref. 16).

Keywords: bronchial asthma, genetic predisposition, HLA-DQB1, HLA-DRB1
Year: 2013, Volume: 114, Issue: 2 Page From: 93, Page To: 95

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