Home 
FOR AUTHORS General Physiology and Biophysics 2013 General Physiology and Biophysics Vol.32, No.2, p.229–234, 2013
FOR AUTHORS General Physiology and Biophysics 2013 General Physiology and Biophysics Vol.32, No.2, p.229–234, 2013
Journal info
Aims and Scope |
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
General Physiology and Biophysics Vol.32, No.2, p.229–234, 2013 |
||
| Title: Effect of TiO2 nanoparticles on emotional behavior and biochemical parameters in adult Wistar rats | ||
| Author: Salem Amara, Wahid Khemissi, Imen Mrad, Naima Rihane, Imen Ben Slama, Lassaad El Mir, Mustapha Jeljeli, Khemais Ben Rhouma, Hafedh Abdelmelek, Mohsen Sakly | ||
| Abstract: The rapidly developing field of nanotechnology is becoming a potential source for human exposure to nanoparticles. Titanium dioxide (TiO2) nanoparticles have been widely produced in industrial processes for several years. The aim of this study was to investigate the effects of TiO2 nanoparticles on plasmatic biochemical parameters and the emotional behavior in adult Wistar rats. Rats were treated by intraperitoneal injection of TiO2 nanoparticles (20–30 nm) at a dose of 25 mg/kg. For toxicity evaluation of nanoparticles sample, body weight, organ coefficient, blood biochemistry panel assay (AST, ALT, LDH, uric acid, creatinine, and glucose content) and emotional behavior parameters were determined. Sub-acute TiO2 nanoparticles treatment decreased the body weight, but increased the relative brain weight. Biochemical assessment in plasma samples showed that TiO2 nanoparticles injection increased uric acid concentration and AST activity in rats. However, the same treatment decreased the creatinine level, but had no effect on glucose concentration, ALT and LDH activity. The emotional behavior of control and treated rats was tested in elevated plus-maze. Interestingly, our results showed that TiO2-treated rats spent more time in the secured closed arms and entered the anxiogenic open arms less frequently than control. Our results suggest that TiO2 nanoparticles intoxication could altered biochemical parameters related to changes in organ function and leads to emotional behavior impairment of rats. |
||
| Keywords: TiO2 nanoparticles — Emotional behavior — Elevated plus maze — Biochemical parameters — Rats | ||
| Published online: 24-Jan-2013 | ||
| Year: 2013, Volume: 32, Issue: 2 | Page From: 229, Page To: 234 | |
| doi:10.4149/gpb_2013015 |
||
|
|
 download file |
|