Home HOME General Physiology and Biophysics 2013 General Physiology and Biophysics Vol.32, No.2, p.245–250, 2013

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.32, No.2, p.245–250, 2013

Title: Mesenchymal stem cells in prostate cancer have higher expressions of SDF-1, CXCR4 and VEGF
Author: Guanxiong Ding, Lujia Wang, Hua Xu, Zheng Xu, Chenchen Feng, Qiang Ding, Zujun Fang, Zhong Wu, Haowen Jiang, Jianfeng Xu, Peng Gao

Abstract: Our previous study found that the activity of PCa-MSCs, which could stimulate the cell proliferation of RM-1, was significantly different compared to BMMSCs. Our results indicated that it could be mediated in part by growth factors/chemokines, which were involved in the different activity between two kinds of MSCs (PCa-MSCs and BMMSCs). Normal MSCs (BMMSCs) were isolated from the femur, tibia of the normal mice; prostate tumor MSCs (PCa-MSCs) were obtained from the mice implanted with prostate tumor. Analysis of the expression of SDF-1, CXCR4, VEGF, bFGF and vWF of two kinds of MSCs were examined by ELISA, Realtime-PCR and Western blotting. The expressions of SDF-1 and CXCR4 in PCa-MSCs were higher compared to BMMSCs. Expressions of bFGF and vWF were higher in PCa-MSCs yet the difference did not reach statistical significance. The expression of VEGF was significantly higher in PCa-MSCs. Our data showed that activity of PCa-MSCs was significantly improved compared with BMMSCs, which seemed to have an intrinsic, cell-specific capacity localized to PCa. It could be induced by some factors or chemokines such as SDF-1, CXCR4, and VEGF. The possible role of PCa-MSCs in the process of PCa development needed further clarification.

Keywords: Mesenchymal stem cells in prostate cancer have higher expressions of SDF-1, CXCR4 and VEGF
Published online: 24-Jan-2013
Year: 2013, Volume: 32, Issue: 2 Page From: 245, Page To: 250

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