General Physiology and Biophysics Vol.32, No.2, p.209

General Physiology and Biophysics Vol.32, No.2, p.209–214, 2013

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.32, No.2, p.209–214, 2013
Title: Attenuation of the insulin amyloid aggregation in presence of Fe3O4-based magnetic fluids
Author: Katarina Siposova, Eva Bystrenova, Andrea Antosova, Martina Koneracka, Vlasta Zavisova, Peter Kopcansky, Zuzana Gazova

Abstract: Presence of protein amyloid deposits is associated with pathogenesis of amyloidrelated diseases. Insulin amyloid aggregates have been reported in a patient with diabetes undergoing treatment by injection of insulin. We have investigated the interference of insulin amyloid aggregation with two Fe3O4-based magnetic fluids. The magnetic fluids are able to inhibit insulin amyloid fibrillization and promote disassembly of amyloid fibrils. The cytotoxic effect of amyloid fibrils is attenuated in presence of magnetic fluids probably due to reduction of the fibrils. We suggest that present findings propose the potential use of Fe3O4-based magnetic fluids as the therapeutic agents targeting insulin-associating amyloidosis.

Keywords: Amyloid aggregation — Insulin — Magnetic fluid — Cell viability
	Published online: 24-Jan-2013
Year: 2013, Volume: 32, Issue: 2	Page From: 209, Page To: 214
doi:10.4149/gpb_2013022
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