Home HOME General Physiology and Biophysics 2013 General Physiology and Biophysics Vol.32, No.2, p.235–243, 2013

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.32, No.2, p.235–243, 2013

Title: Long-term effect of prazosin and losartan administration on blood pressure, heart, carotid artery, and acetylcholine induced dilation of cardiovascular system of young Wistar rats and SHR
Author: Frantisek Kristek, Magdalena Malekova, Sona Cacanyiova

Abstract: The long-term effects of prazosin and losartan administration on blood pressure (BP), trophicity of the heart and carotid arteries (CA), and responses of the cardiovascular system (CVS) to acetylcholine, were studied in Wistar rats and SHRs. Four-week-old rats were treated with prazosin (10 mg/kg b.w./day in tap water) or losartan (20 mg/kg b.w./day in tap water) for 5–6 weeks. BP was measured by plethysmographic method. Ten animals of each group were subjected to in vivo studies and subsequent to morphological investigations. The right jugular vein was cannulated for administration of acetylcholine (0.1, 1 and 10 µg). After perfusion with a glutaraldehyde fixative (120 mmHg), the CA were embedded in Durcupan ACM, and the inner diameter (ID), wall thickness (WT) (tunica intima and media), cross sectional area (CSA) (tunica intima and media), and WT/ID ratio were calculated. In Wistar rats and SHRs, prazosin and losartan administration produced a decrease in the BP and trophicity of the heart. In Wistar rats, both drugs decreased the WT, CSA, and the WT/ID ratio. In addition, these drugs increased the circumferential stress of the artery without affecting the ID. In contrast, in the SHRs, only losartan administration produced these effects. Importantly, both the drugs improved the responses to acetylcholine in SHRs.

Keywords: Carotid artery — Prazosin — Losartan — Structure — Acetylcholine responses
Published online: 26-Feb-2013
Year: 2013, Volume: 32, Issue: 2 Page From: 235, Page To: 243

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