Home HOME General Physiology and Biophysics 2013 General Physiology and Biophysics Vol.32, No.1, p.115–127, 2013

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.32, No.1, p.115–127, 2013

Title: Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats
Author: Hichem Alimi, Sakhria Mbarki, Zeineb Ben Barka, Anwer Feriani, Zouhour Bouoni, Najla Hfaeidh, Mohsen Sakly, Olfa Tebourbi, Khémais Ben Rhouma

Abstract: Rhus tripartitum (sumac) is an Anacardiaceae tree with a wide phytotherapeutic application including the use of its roots in the management of gastric ulcer. In the present study the Rhus tripartitum root barks extract (RTE) was phytochemical studied, in vitro tested for their potential antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and reducing power assay and in vivo evaluated for its ability to prevent ethanol-induced gastric ulcer in rats. The RTE was rich in phenolics, flavonoids, tannins and polysaccharide contents and exhibited a low but not weak in vitro antioxidant activity when compared with (+)-catechin. Pre-treatment with RTE at oral doses 50, 200 and 400 mg/kg body weight was found to provide a dose-dependent protection against ethanol-induced ulcer by averting the deep ulcer lesions of the gastric epithelium, by reducing gastric juice and acid output, by enhancing gastric mucus production by preserving normal antioxidant enzymes activities, and inhibiting the lipid peroxidation. The antiulcerogenic activity of RTE might be due to a possible synergistic antioxidant and antisecretory effects.

Keywords: Rhus tripartitum — Polysaccharide — Tannin — Antioxidant — Antiulcerogenic
Year: 2013, Volume: 32, Issue: 1 Page From: 115, Page To: 127
doi:10.4149/gpb_2013003


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