Home General Physiology and Biophysics 2013 General Physiology and Biophysics Vol.32, No.1, p.139–142, 2013

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.32, No.1, p.139–142, 2013

Title: Brain-derived neurotrophic factor blood levels in two models of transient brain ischemia in rats
Author: Miroslav Gottlieb, Petra Bonova, Viera Danielisova, Miroslava Nemethova, Jozef Burda, Dasa Cizkova

Abstract: We monitored possible influence of transient focal and global brain ischemia on BDNF blood level. In both models noticeable fluctuation of BDNF concentration mainly in reperfusion was observed. During the first 90 min, BDNF in total blood and in blood cells continuously decreased in both models but plasma BDNF raised at 40 min and peaked at 90 min of reperfusion. Our data confirm the impact of transient brain ischemia on BDNF levels in the circulatory system, suggest blood cells as a possible source of BDNF and demonstrate the interdependence of blood compartments and physiological state of an affected organism.

Keywords: BDNF — Brain — Global ischemia — Focal ischemia — Blood
Year: 2013, Volume: 32, Issue: 1 Page From: 139, Page To: 142
doi:10.4149/gpb_2013008


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