Home General Physiology and Biophysics 2013 General Physiology and Biophysics Vol.32, No.2, p.173–177, 2013

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.32, No.2, p.173–177, 2013

Title: Influence of naturally occurring antioxidants on magnetic nanoparticles: Risks, benefits, and possible therapeutic applications
Author: Štefan Durdík, Hanka Vrbovská, Adam Olas, Melánia Babincová

Abstract: We have studied interaction of well known antioxidant L-ascorbic acid with magnetic nanoparticles containing insoluble Fe(III) in their core. In analogy with ferritin, mobilization of iron in the form of water soluble Fe(II) was observed, especially pronounced at highertemperatures. In the presence of hydrogen peroxide cytotoxic hydroxyl radicals are produced. These results suggest possible harmful effects of widely used magnetic nanoparticles as a MRI contrast agents in combination with overload of organism with ascorbic acid in some specific conditions, like fever of patient. On the other hand combination of magnetic nanoparticles and ascorbic acid may be used for a cancer therapy using alternating magnetic field for the release of Fe(II) via Néel relaxation of magnetic moment of used nanoparticles. We have further found that lipoic acid is an efficient antioxidant scavenging hydroxyl radicals produced by Fenton reaction from Fe(II).

Keywords: Magnetic nanoparticles — Toxicity — Oxidative stress — Antioxidants — Cancer therapy
Published online: 13-Mar-2013
Year: 2013, Volume: 32, Issue: 2 Page From: 173, Page To: 177
doi:10.4149/gpb_2013039


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