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General Physiology and Biophysics 2013 General Physiology and Biophysics Vol.32, No.3, p.347–359, 2013
General Physiology and Biophysics 2013 General Physiology and Biophysics Vol.32, No.3, p.347–359, 2013
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General Physiology and Biophysics Vol.32, No.3, p.347–359, 2013 |
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| Title: Epilobium angustifolium extract demonstrates multiple effects on dermal fibroblasts in vitro and skin photo-protection in vivo | ||
| Author: Ema Ruszová, Jose Cheel, Stanislav Pávek, Martina Moravcová, Martina Hermannová, Ilona Matějková, Jiřina Spilková, Vladimír Velebný, Lukáš Kubala | ||
| Abstract: Stress-induced fibroblast senescence is thought to contribute to skin aging. Ultraviolet light (UV) radiation is the most potent environmental risk factor in these processes. An Epilobium angustifolium (EA) extract was evaluated for its capacity to reverse the senescent response of normal human dermal fibroblasts (NHDF) in vitro and to exhibit skin photo-protection in vivo. The HPLC-UV-MS analysis of the EA preparation identified three major polyphenolic groups, which were tannins (oenothein B), phenolic acids (gallic and chlorogenic acids) and flavonoids. EA extract increased the cell viability of senescent NHDF induced by serum deprivation. It diminished connective tissue growth factor and fibronectin gene expressions in senescent NHDF. EA extract down-regulated the induced release of both matrix metalloproteinase -1 and -3 and the tissue inhibitor of matrix metalloproteinases -1 and -2, and also down-regulated the gene expression of hyaluronidase 2 in repeatedly UV-irradiated NHDF. EA extract diminished the down-regulation of sirtuin 1 dampened by UV-irradiation. The application of EA extract using a sub-irritating dose protected skin against UV-induced erythema formation in vivo. In summary, EA extract diminished stress-induced effects on NHDF, particularly on connective tissue growth factor, fibronectin and matrix metalloproteinases. These results collectively suggest that EA extract may possess anti-aging properties and that the EA polyphenols might account for these benefits. |
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| Published online: 13-Mar-2013 | ||
| Year: 2013, Volume: 32, Issue: 3 | Page From: 347, Page To: 359 | |
| doi:10.4149/gpb_2013031 |
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