Home Bratislava Medical Journal 2013 Bratislava Medical Journal Vol.114, No.4, p.183–188, 2013

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.114, No.4, p.183–188, 2013

Title: Thyroid hormones-mediated effects of insulin on antioxidant enzymes from diabetic rat hearts
Author: F. Kosova, N. Altan, A. Sepici, A. Engin, N. Kocamanoglu

Abstract: Free radicals, oxidative stress, and antioxidants have become commonly used terms in modern discussion of disease mechanisms. Accumulation of evidence suggests that toxic oxygen-derived reactive free radicals (superoxide, peroxide and hydroxyl radicals) play a crucial role in etiology of diabetes and its complication. Thus, it was aimed to determine the role of thyroid hormones in reversal of antioxidatant enzyme activities and lipid peroxidation alterations observed in experimentally induced diabetic rat hearts. The present study investigates the antioxidant enzyme activities such as SOD, CAT, GSH-Px and lipid peroxidation products in cardiac tissues of streptozotosin (STZ)-induced diabetic rats before and after thyroidectomy.
Our results showed that CAT, GPx enzyme activities and FOX, MDA levels were increased (pyroidism and hypothyroidism with diabetes, which can be regulated in different percentages with treatment of insulin and various doses of thyroid hormone (piac tissue and serum of rat has been seen (Tab. 5, Ref. 32).

Keywords: diabetes mellitus, thyroid hormone, superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), malondialdehyde (MDA), ferrous oxidation in xylenol orange (FOX)
Year: 2013, Volume: 114, Issue: 4 Page From: 183, Page To: 188

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