Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Current articles 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Acta Virologica Vol.57, No.1 p.69-74, 2013 |
||
Title: Anti-neoplastic effect of avian reovirus σ C protein on Rous sarcoma virus-induced tumors in chicken | ||
Author: R. UMA, M. KATARIA, S. RAHUL, J. M. KATARIA | ||
Abstract: This study investigated the anti-neoplastic potential of avian reovirus σC (sigma C) protein on Rous sarcoma virus-induced fibrosarcoma in chicken. The recombinant vector expressing σC protein was injected intra-tumorally into specific pathogen free chicken with fibro-sarcoma at the dose 100µg per bird, while control birds were mock-treated with 100µg of empty vector per bird. Recombinant σC protein induced apoptosis in tumors of treated birds resulting in progressive tumor regression, while similar changes were absent in tumors of mock-treated controls. The σC protein-induced apoptosis in tumors was quantified by flow cytometry and the mean level of apoptosis up to 66% was observed in treated tumors, whereas any significant level of apoptosis was absent in mock-treated controls. |
||
Keywords: avian reovirus; Rous sarcoma virus; tumors; σC protein; apoptosis | ||
Year: 2013, Volume: 57, Issue: 1 | Page From: 69, Page To: 74 | |
doi:10.4149/av_2013_01_69 |
||
Price:
14.40 €
|
||
|
||