Home Acta Virologica 2013 Acta Virologica Vol.57, No.1 p.85-86, 2013

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

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Acta Virologica Vol.57, No.1 p.85-86, 2013

Title: Homonojirimycin, an alkaloid from dayflower inhibits the growth of influenza A virus in vitro
Author: G.- B. ZHANG, B. ZHANG, X.- X. ZHANG, F.- H. BING

Abstract: We have previously examined the antiviral effects of total alkaloids from Commelina communis L. (TAC). Here we investigated the active constituents of TAC, responsible for the antiviral effect. Harman, homonojirimycin (HNJ) and 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine were isolated from TAC by HPLC. Only HNJ showed strong antiviral activity against influenza A/PR/8/34 virus (H1N1) as measured by cytopathic effect reduction assay. The results suggest that HNJ is one of the active components of TAC.

Keywords: Commelina communis L.; influenza A virus; alkaloids; homonojirimycin
Year: 2013, Volume: 57, Issue: 1 Page From: 85, Page To: 86
doi:10.4149/av_2013_01_85
Price: 4.80 €






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