Neoplasma Vol.60, No.4, p.419-424, 2013
|Title: Diagnostic value of thiols, paraoxonase 1, arylesterase and oxidative balance in colorectal cancer in human|
|Author: N. Bulbuller, E. Eren, H. Y. Ellidag, O. Z. Oner, C. Sezer, O. Aydin, N. Yılmaz|
Oxidative stress has been shown to play an important role in carcinogenesis. We hypothesize that serum oxidative and anti-oxidative factors work together to influence colon and rectal cancer through an oxidative balance mechanism. Total thiol (Ttl) is considered a plasma antioxidant and high density lipoprotein (HDL)- dependent paraoxonase l (PON1) is known as a free radical scavenger. This study was undertaken to determine the activity of PON1, arylesterase (ARE) and Ttl levels and oxidative balance in colorectal cancer (CRC) patients and healthy subjects.
Decreased Ttl and HDL-dependent PON 1 enzyme activities and high TOS levels imply an imbalance of the free radical system which enhances the support the hypothesis that CRC is associated with excess reactive oxygen species.These findings show that of serum oxidative imbalance was associated with an increased risk of CRC. To our knowledge, this is the first report demonstrating lower serum PON1, ARE activities in CRC patients. The mechanism behind this association needs further elucidation.
|Keywords: Colon Cancer, Thiols, Oxidative Stress|
|Published online: 12-Apr-2013|
|Year: 2013, Volume: 60, Issue: 4||Page From: 419, Page To: 424|