Home HOME Neoplasma 2013 Neoplasma Vol.60, No.4, p.439-445, 2013

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.60, No.4, p.439-445, 2013

Title: Upregulated Hoxc6 expression is associated with poor survival in gastric cancer patients
Author: Q. Zhang, X. S. Jin, Z. Y. Yang, M. Wei, B. Y. Liu, Q. L. Gu

Abstract: Human Hox genes (Homeobox) have crucial roles in development and differentiation, regulating numerous processes including apoptosis, receptor signalling, differentiation, motility and angiogenesis. Aberrant expression of Hoxc6 gene has been reported in several tumor tissues and cancer cell lines. The prognostic significance of Hoxc6 in gastric cancer remains largely unknown.This study was aimed to investigate the clinical significance of Hoxc6 in gastric cancer.
Total RNA of paired tissue samples (n=25) and a tissue microarray containing 161 paired tissues from patients with gastric cancers at different stages were collected. Quantitative real-time PCR and immunochemistry assay were carried out to investigate the expression of Hoxc6.
Hoxc6 mRNA was increased in gastric cancer tissues ( 16 of 25) compared with the adjacent normal mucosa (P<0.05). Immunohistochemical detection showed that expression of Hoxc6 was associated with the depth of tumor invasion (P<0.05). Patients with higher expression levels of Hoxc6 had a shorter overall survival rate (P<0.05).
Hoxc6 might contribute to the progression of gastric carcinogenesis and may be a significant predictor of poor survival in patients with gastric cancer after curative operations.

Keywords: gastric cancer, Hoxc6 gene, tissue microarray, prognostic marker
Published online: 12-Apr-2013
Year: 2013, Volume: 60, Issue: 4 Page From: 439, Page To: 445

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