Home Acta Virologica 2013 Acta Virologica Vol.57, No.2 p.91-96, 2013

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Quarterly, 72-88 pp. per issue
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.57, No.2 p.91-96, 2013

Title: Overview of measles and mumps vaccine: origin, present, and future of vaccine production
Author: T. BETÁKOVÁ, D. SVETLÍKOVÁ, M. GOCNÍK

Abstract: Measles and mumps are common viral childhood diseases that can cause serious complications. Vaccination remains the most efficient way to control the spread of these viruses. The manufacturing capability for viral vaccines produced in embryonated hen eggs and conventional/classical cell substrates, such as chicken embryo fibroblast or primary dog kidney cell substrates, is no longer sufficient. This limitation can be overcome by utilizing other recognized cell substrates such as Madin Darby Canine Kidney (MDCK), Chinese Hamster Ovary (CHO), Vero (monkey origin) cells, MRC-5 (human diploid) or as an alternative, introducing new cell substrates of human or avian origin. A very important factor in vaccine production is the safety and immunogenicity of the final vaccine, where the proper choice of cell substrate used for virus propagation is made. All substrates used in vaccine production must be fully characterized to avoid the contamination of hidden unknown pathogens which is difficult to achieve in primary cell substrates.

Keywords: measles virus; mumps virus; vaccines; cell substrates
Year: 2013, Volume: 57, Issue: 2 Page From: 91, Page To: 96
doi:10.4149/av_2013_02_91


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