JournalsActa Virologica 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Bratislava Medical Journal Ekologia - Ecology Endocrine Regulations General Physiology and Biophysics Neoplasma Studia Psychologica Psychológia a patopsych. dieťaťa Building Research Journal Metallic Materials Slovenská hudba Musicologica Slovaca
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Acta Virologica Vol.57, No.2 p.91-96, 2013
|Title: Overview of measles and mumps vaccine: origin, present, and future of vaccine production|
|Author: T. BETÁKOVÁ, D. SVETLÍKOVÁ, M. GOCNÍK|
|Abstract: Measles and mumps are common viral childhood diseases that can cause serious complications. Vaccination remains the most efficient way to control the spread of these viruses. The manufacturing capability for viral vaccines produced in embryonated hen eggs and conventional/classical cell substrates, such as chicken embryo fibroblast or primary dog kidney cell substrates, is no longer sufficient. This limitation can be overcome by utilizing other recognized cell substrates such as Madin Darby Canine Kidney (MDCK), Chinese Hamster Ovary (CHO), Vero (monkey origin) cells, MRC-5 (human diploid) or as an alternative, introducing new cell substrates of human or avian origin. A very important factor in vaccine production is the safety and immunogenicity of the final vaccine, where the proper choice of cell substrate used for virus propagation is made. All substrates used in vaccine production must be fully characterized to avoid the contamination of hidden unknown pathogens which is difficult to achieve in primary cell substrates.
|Keywords: measles virus; mumps virus; vaccines; cell substrates|
|Year: 2013, Volume: 57, Issue: 2||Page From: 91, Page To: 96|