Acta Virologica Vol.57, No.2 p.97-104, 2013

Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Acta Virologica Vol.57, No.2 p.97-104, 2013
Title: Role and application of RNA interference in replication of influenza viruses
Author: T. BETÁKOVÁ, P. ŠVANČAROVÁ

Abstract: RNA interference (RNAi) is a naturally occurring endogenous biological post-transcriptional cellular mechanism that regulates RNA expression. Small interfering RNAs (siRNAs), mediators of RNAi, are short (19–26nt), double-stranded RNA duplexes that inhibit gene expression by inducing sequence-specific degradation of homologous messenger RNA (mRNA). Influenza virus infection is a major public health problem, causing hundreds of thousands of deaths worldwide each year. RNAi have provided a means to performing genome-wide screens to determine and validate host cell genes that may be required for influenza replication and treatment with siRNA specific to regions of the influenza genes which can inhibit influenza virus replication. Moreover, influenza virus is using small RNA in the regulation of virus replication and in modulation of the innate immune signalling system of the host.

Keywords: influenza virus; RNA interference; siRNA; miRNA; replication; transcription

Year: 2013, Volume: 57, Issue: 2	Page From: 97, Page To: 104
doi:10.4149/av_2013_02_97
	download file

Aepress.sk