Home Acta Virologica 2013 Acta Virologica Vol.57, No.2 p.200-216, 2013

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

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Acta Virologica Vol.57, No.2 p.200-216, 2013

Title: Immunomodulators in tick saliva and their benefits

Abstract: Ticks are significant bloodsucking ectoparasites. Apart from causing blood loss and host skin damage, ticks are important vectors of tick-borne pathogens that cause disease in humans and animals as well as significant economic loss. For biological success, ticks evolved these substances with immunomodulatory activities capable of inhibiting host defence reactions (haemostasis, inflammation and immunity reactions), and which have a radical significance for their survival. The resulting feeding site represents a favourable environment and many pathogens began exploiting ticks to facilitate their transmission to the host. The structural-functional relationships of some salivary compounds have been outlined; however research on tick sialomas indicates that further extensive exploration is required on the subject. Also, tick saliva is a complex pharmacological component with great therapeutic potential for the treatment for some diseases.

Keywords: ticks; tick saliva; immunomodulation; haemostasis; inflammation; therapeutical tools
Year: 2013, Volume: 57, Issue: 2 Page From: 200, Page To: 216

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