Home Acta Virologica 2013 Acta Virologica Vol.57, No.2 p.257-264, 2013

Journal info

Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

Aims and Scope
Abstracted and Indexed

Select Journal

Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Acta Virologica Vol.57, No.2 p.257-264, 2013

Title: Modulation of cell surface density of carbonic anhydrase IX by shedding of the ectodomain and endocytosis

Abstract: Carbonic anhydrase IX (CA IX) is a cell surface protein frequently present in human tumors but not in the corresponding normal tissues. Expression of CA IX is primarily determined by the strong transcriptional activation of the gene encoding CA IX by hypoxia via the hypoxia-inducible transcription factor HIF-1. However, the ultimate abundance of the CA IX protein on the cell surface can be affected by additional mechanisms, including ectodomain shedding and endocytosis. In this paper, we summarize the basic knowledge on how these processes modulate CA IX expression at the post-translational level. We propose that the regulation of the CA IX protein residence in the plasma membrane can influence its biological function as well as its clinical exploitation.

Keywords: carbonic anhydrase IX; ADAM17; ectodomain shedding; proteolysis; endocytosis; monoclonal antibody; hypoxia; cancer
Year: 2013, Volume: 57, Issue: 2 Page From: 257, Page To: 264

download file

© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.