Home Bratislava Medical Journal 2013 Bratislava Medical Journal Vol.114, No.5, p.283-286, 2013

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.114, No.5, p.283-286, 2013

Title: The long-term response to treatment with calcium channel blockers in a patient with idiopathic pulmonary arterial hypertension.
Author: P. Solik, P. Lesny, M. Luknar, I. Varga, E. Goncalvesova

Abstract: Pulmonary arterial hypertension (PAH) is a disease characterised by a gradual increase in resistance of pulmonary circulation leading to right ventricular failure and death. In only 10 % of cases, there is a response to acute vasoreactivity testing with a significant reduction in mean pulmonary artery pressure (PAP), while in this group of patients, less than one half of cases benefit from long-term treatment with calcium channel blockers (CCB). This paper describes a case report of a young patient with dyspnoea and suspicion of pulmonary hypertension who was referred to a specialised centre. The complex evaluation of her clinical state led to confirmed diagnosis of idiopathic pulmonary arterial hypertension (IPAH). Because there was a positive response to vasoreactivity testing, the treatment for IPAH was initiated with a high dose of CCB. This treatment markedly improved her clinical state as well as echocardiographic and hemodynamic findings.
In this study, the authors present a diagnostic algorithm in pulmonary hypertension and emphasise the role of CCB in treatment of PAH in carefully selected patients (Tab. 1, Fig. 5, Ref. 7).

Keywords: pulmonary hypertension, pulmonary arterial hypertension, acute vasoreactivity testing, treatment, calcium channel blockers.
Year: 2013, Volume: 114, Issue: 5 Page From: 283, Page To: 286

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