Home HOME Endocrine Regulations 2013 Endocrine Regulations Vol.47, No.2, p.57–64, 2013

Journal info

Quarterly, 50 pp. per issue 
Founded: 1967
ISSN 1210-0668
E-ISSN 1336-0329

Published in English

Aims and Scope
Editorial Info
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Endocrine Regulations Vol.47, No.2, p.57–64, 2013

Title: Increased serum interleukin-33 levels in patients with Graves’ disease
Author: H. T. Celik, S. Abusoglu, S. F. Burnik, S. Sezer, M. A. Serdar, M. Ercan, N. Uguz, M. Avcikucuk, Bal Ceylan, M. Yildirimkaya

Abstract:

Objective. Interleukin-33 (IL-33), a 30 kDa cytokine, is a member of IL-1 family. It is considered to be an autoimmune biomarker associated with T helper 2 (Th 2) response. γ-interferon is also produced by T helper 1 (Th 1) cells to induce cellular responses. γ-interferon is a 143-amino acid residue glycoprotein with several biological functions including potent anti-viral activity, stimulation of macrophage activity, modulation of Major Histocompatibilty Complex class I/class II expression, and regulation of a diversity of specific immune responses. The aim of this study was to investigate the serum levels of IL-33 and γ-interferon in different thyroid disorders.
Methods. Twenty patients with Graves’ disease, 21 patients with Hashimoto hypothyroidism, 21 euthyroid Hashimoto patients, and 27 control subjects were recruited to this study. Blood samples were drawn and IL-33 and γ-interferon tests were analyzed from 89 participants. Serum IL-33 and γ-interferon analyses were performed by enzyme-linked immunosorbent assay.
Results. There was no statistically significant difference between groups for serum γ-interferon levels. Serum IL-33 concentrations were significantly higher in Graves’ disease group compared to the other groups (p<0.000) There was a positive correlation between serum IL-33 and free triiodothyronine (fT3) and thyroxine (fT4). Also, negative correlation between serum IL-33 and thyroid-stimulating hormone (TSH) was statistically significant (p<0.000).

Conclusions. The correlation of serum IL-33 with thyroid hormone levels may be a useful indicator for Graves’ disease. These findings may help to make evident the pathophysiologic processes of the autoimmune thyroid diseases and improve therapeutic methods.



Keywords: interleukin, hyperthyroiditis, Hashimoto thyroiditis, cytokines, thyroid disorders
Year: 2013, Volume: 47, Issue: 2 Page From: 57, Page To: 64
doi:10.4149/endo_2013_02_57
Price: 16.00 €






© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.