Bratislava Medical Journal Vol.114, No.6, p.317-322, 2013
|Title: The effects of nitrous oxide on vitamin B12 and homocysteine levels in methyltetrahydrofolate reductase gene mutation|
|Author: S. Hakimoglu, V. Hanci, Y. Hakimoglu, S. Cicek, S. Yurtlu, R. D. Okyay, H. Ayoglu, M. Can, G. Mungan, A. Dursun, I. Turan|
Background: We aimed to investigate the effects of nitrous oxide on plasma total homocysteine and vitamin B12 levels in patients with or without methyltetrahydrofolate reductase (MTHRF) gene mutation.
Postoperative vitamin B12 levels were found to be significantly lower when compared with their preoperative levels (p<0.05).
It was found that MTHRF gene polymorphism had no significant effect on postoperative plasma total homocysteine and serum vitamin B12 levels (p>0.05).
Postoperative plasma total homocysteine levels were found to be significantly different between patients with operation times under and over 3 hours (p=0.028).
|Keywords: nitrous oxide, general anesthesia, homocysteine, vitamin B12, methyltetrahydrofolate reductase.|
|Year: 2013, Volume: 114, Issue: 6||Page From: 317, Page To: 322|