Home Neoplasma 2013 Neoplasma Vol.60, No.5, p.553-561, 2013

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ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.60, No.5, p.553-561, 2013

Title: Clinical importance of myeloid antigen expression in Moroccan patients with adult B-lineage acute lymphoblastic leukemia.
Author: A. Lahjouji, F. Bachir, S. Bennani, S. Benchekroun, S. Amzazi,R. E. Aouad


The prognostic significance of myeloid antigen (MyAg) expression in acute lymphoblastic leukemias (ALL), especially in adult patients, is still controversial.

In the present report, frequency and clinical significance of MyAg (CD13 and/or CD33) in blast cells were assessed in 80 consecutive adult (≥18 years) patients with B-lineage acute lymphoblastic leukemia (B-ALL), representing 66.7% of 120 patients diagnosed as having ALL during the study period.

Immunophenotyping was used to classify leukemic cells as B or T lymphoblasts and to identify the aberrant expression of myeloid-associated antigens. MyAg expression was documented in 52.5% of the 80 B-ALL cases analyzed. CD13 was the most commonly antigen expressed (36.3%) followed by CD33 (28.8%).

No significant associations were found between the expression of MyAg and the presence of known adverse prognostic features (eg: age>30 years, male gender, high WBC count and Philadelphia positivity).

Also, we failed to observe any statistically significant difference between MyAg-positive and MyAg-negative patients in terms of achievement of complete remission and overall survival at 3 years. This study demonstrates that the presence of MyAg on lymphoblastic cells lacks prognostic value In Moroccan patients with adult B-ALL.

Keywords: adult B acute lymphoblastic leukemia, myeloid antigen, immunophenotyping, prognosis
Published online: 24-Jun-2013
Year: 2013, Volume: 60, Issue: 5 Page From: 553, Page To: 560

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