Home Bratislava Medical Journal 2013 Bratislava Medical Journal Vol.114, No.7, p.365-368, 2013

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.114, No.7, p.365-368, 2013

Title: A decrease of the rabbit’s physiologic IOP after the application of specific amino acids and double combination of antiglaucomatics mixture
Author: Z. Olah, J. Veselovsky

Abstract: Purpose: To compare the effect of amino acids mixtures to a double combination of antiglaucomatics on the physiologic intraocular pressure (IOP) in rabbits.
Methods: Experimental evaluations were performed on 5 female rabbits of the New Zealand White species.
Results: 1) After instillation of 10 % L-arginine. HCl in the double combination of antiglaucomatics: a) 0.5 % Timolol with 0.005 % Xalatan mixture, the biphasic IOP decrease was measured. The mean decrease in 24 hours was – 2.9 torr; b) 2 % Trusopt with 0.005 % Xalatane mixture in 24 hours, the biphasic decrease of the IOP was measured. The mean decrease in 24 hours was – 4.2 torr; c) Fixed combination COSOPT the mean IOP value decrease was – 1.8 torr. 2) The IOP decrease achieved during 24 hours by instillation of the amino acid 10 % L-taurine.HCl and the double combination of antiglaucomatics: 0.5% Timolol with 0.005% Xalatane mixture was in average – 2.8 torr. The pupilar diameter was not changed.
Conclusions: We assume that after the interaction of the selected amino acids 10 % L-arginin or 10 % L-taurin with the double combination of antiglaucomatics (Trusopt and Xalatan, COSOPT or Timoptol and Xalatan) a new substance was formed. The effect of this substance is not separate or additive but acts as a newly formed substance. In vivo, it is only a weak interaction with the free amino acids of the conjunctival sac and the antiglaucomatics. The amino acids interacted in vitro with the double combination of antiglaucomatics resulting in a new „bio-antiglaucomatic“ better penetrating into the target area. This new substance was responsible for a more significant decrease and regulation IOP after the mixture application compared to the antiglaucomatics alone (Fig. 1, Ref. 23).

Keywords: IOP influence in experiment, rabbits IOP after mixture, amino acids arginine, taurine, double combination of antiglaucomatics.
Year: 2013, Volume: 114, Issue: 7 Page From: 365, Page To: 368

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