Home Neoplasma 2013 Neoplasma Vol.60, No.6, p.690-697, 2013

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.60, No.6, p.690-697, 2013

Title: Endotelial activation and flow-mediated vasodilation in young patients with breast cancer
Author: P. Tesarova, M. Kalousova, T. Zima, M. Suchanek, I. Malikova, J. Kvasnicka, D. Duskova, V. Tesar, J. Vachek, Z. Krupickova-Kasalova, J. Malik


Endothelial activation and dysfunction may play a significant role in the progression of breast cancer. In our study we examined markers of endothelial activation (soluble ICAM-1, P-selectin, E-selectin) in 98 young patients with breast cancer (< 40 years).

In 50 of them (and 20 age-matched controls) we also measured flow mediated vasodilation. Patients with breast cancer had significantly higher serum levels of soluble E-selectin, P-selectin and ICAM-1, P-selectin was higher in patients with larger tumors, node involvement and seemed to be a predictor of poor outcome. We were unable to find significant difference in the parameters of flow mediated vasodilation between patients with breast cancer and healthy subjects, although both peak blood flow (PBF) and flow mediated vasodilation (FMD) seemed to be skewed compared to healthy subjects toward mean and lower levels. Cluster analysis enabled us to distinguish several larger groups of patients with different degree of endothelial activation and function and different outcome. Group of patients with high E-selectin, high ICAM-1 (higher endothelial activation) and low VEGF (putative endothelial damage) had more frequently negative estrogen receptors and had worse outcome compared to the group of patients with lower E-selectin, lower ICAM-1 and mostly positive estrogen receptors. Further studies of larger groups of patients should help to identify the pannel of endothelial markers which could help in predicting the outcome of young patients with breast cancer.

Keywords: breast cancer, endothelial dysfunction, flow mediated vasodilation, adhesion molecules
Published online: 01-Aug-2013
Year: 2013, Volume: 60, Issue: 6 Page From: 690, Page To: 697

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