Journal info
Aims and Scope |
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
General Physiology and Biophysics Vol.33, No.1, p.53–62, 2014 |
||
Title: Cisplatin enhances the efficacy of 5-Aminolevulinic acid mediated photodynamic therapy in human head and neck squamous cell carcinoma | ||
Author: Jin-Chul Ahn, Raktim Biswas, Arindam Mondal, Young-Ki Lee, Phil-Sang Chung | ||
Abstract: Photodynamic therapy (PDT) has become a promising option for the treatment of head and neck, and other forms of cancer. 5-Aminolevulinic acid (ALA) is one of the popular photosensitizers used in PDT. It is a heme precursor and is converted to a photosensitizer protophorphyrin IX. In this present study, the combination of anticancer drug cisplatin (CDDP) and ALA mediated PDT was used to study the cytotoxicity in vitro as well as in vivo. Human head and neck cancer cells AMC-HN3 were treated with cisplatin and ALA mediated PDT individually, and also in combination. Several approaches like confocal microscopic study, cytotoxicity assay etc. have been performed to study the intracellular accumulation of protophorphyrin IX in cells and its effectiveness in PDT, when treated in combination with chemotherapy drug, cisplatin (CDDP). The combination of treatments efficacy was also studied in tumor xenograft model. Compared to the individual treatments, combination of CDDP and PDT was found to be more cytotoxic in AMC-HN3, and also more effective in reducing the tumor volume in mice xenograft. Thus with the combined therapy, not only the efficacy of treatment can be enhanced, but the doses of the drugs can also be lowered. This in turn can reduce the side effects of the chemotherapy drugs. Therefore, this study may lead to a potential drug- PDT combination that may be a useful treatment modality for human head and neck cancer. |
||
Keywords: Cisplatin — ALA — Photodynamic therapy — Head and neck cancer | ||
Published online: 02-Aug-2013 | ||
Year: 2014, Volume: 33, Issue: 1 | Page From: 53, Page To: 62 | |
doi:10.4149/gpb_2013046 |
||
|
download file |
|