Home Bratislava Medical Journal 2013 Bratislava Medical Journal Vol.114, No.8, p.425-430, 2013

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.114, No.8, p.425-430, 2013

Title: Effect of intra-abdominal volume increment on lungs in hemorrhagic shock
Author: D. Liu, H. Tan, L. Zhang, Z. Wang, H. Ge, W. Zhang, S. Sun, H. Xiao, X. Huang


Intra-abdominal hypertension (IAH) causes lung dysfunction in patients after hemorrhagic shock resuscitation. We performed intra-abdominal volume increment (IAVI) to IAH and studied its effect on pulmonary function.

Methods: Eight minipigs established for IAH model by exsanquination until shock, incomplete blockage of portal vein and overload resuscitation were randomly divided into IAVI group (n=4) and sham-operated control group (n=4).

Bladder pressure, arterial blood gas analysis and thoraco-abdominal computed tomography (CT) scans were measured. The minipigs were sacrificed 26 h after surgery, and lung samples were harvested for measuring the wet-to-dry weight ratio and hematoxylin–eosin staining.
Results: Compared with sham-operated control group, the respiratory rate and paCO2 remarkably decreased and paO2 notably increased at 8 and 12 h in the IAVI group. The bladder pressure also notably decreased at 8, 12, and 22 h after IAVI treatment. However, a significant improvement in diaphragm height was observed at 22 h after IAVI treatment. The wet-to-dry weight ratio of the lungs in IAVI group was also significantly higher than that that in the sham-operated control group.

Keywords: hemorrhagic shock, resuscitation, IAH, CT, intra-abdominal volume increment, lung, minipig.
Year: 2013, Volume: 114, Issue: 8 Page From: 425, Page To: 430

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