Home Bratislava Medical Journal 2013 Bratislava Medical Journal Vol.114, No.9, p.514-518, 2013

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.114, No.9, p.514-518, 2013

Title: Comparison of propofol-dexmedetomidine, tiopental-dexmedeto- midine and etomidate-dexmedetomidine combinations’ effects on the tracheal intubation conditions without using muscle relaxants
Author: K. Bollucuoglu, V. Hanci, S. Yurtlu, D. Okyay, H. Ayoglu, I. O. Turan


Background: In our study, we aimed to compare the endotracheal intubation conditions without muscle relaxants during induction with the combinations of dexmedotimidine-propofol, dexmedotimidine-thiopenthal and dexmedetomidine-etomidate.
Method: Seventy-six patients, in ASA risk group I-II, between ages 20–60 years, with Mallampati Class 1 were included in the study. All patients were premedicated with midazolam.

The patients were randomly divided into three groups as Group P (n=30, dexmedetomidine-propofol), Group T (n=30, dexmedetomidine-thiopenthal), Group E (n=16, dexmedetomidine-etomidate).

All patients received dexmedetomidine 1 μg.kg-1 in 10 min. Then, the patients were administered 2.5 mg.kg-1 propofol for Group P, 5 mg.kg-1 thiopental for Group T and 0.3 mg.kg-1 etomidate for Group E during induction. Hemodynamic data of the patients were recorded before induction, after dexmedetomidine administration, immediately after intubation and 3, 5 and 10 minutes after intubation.
Results: There was no difference between the groups according to hemodynamic data. Sixteen patients in Group P and 10 patients in Group T had acceptable intubation conditions.

Muscle relaxant was needed in 14, 20 and 16 patients in Groups P, T and E, respectively (p<0.05).

Conclusion: In conclusion, we determined that best intubation conditions without muscle relaxants were achieved with propofol-dexmedetomidine combination. None of the patients receiving etomidate -dexmedetomidine combination could be intubated without muscle relaxants (Tab. 6, Ref. 29).

Keywords: intubation without muscle relaxants, propofol, thiopental, etomidate, dexmedetomidine.
Year: 2013, Volume: 114, Issue: 9 Page From: 514, Page To: 518

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