Acta Virologica Vol.57, No.3, p.293-304, 2013

Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.57, No.3, p.293-304, 2013
Title: Potential roles of protein disulphide isomerase in viral infections
Author: D. DIWAKER, K. P. MISHRA, L. GANJU

Abstract: Protein disulphide isomerase (PDI) family members are predominantly endoplasmic reticulum (ER)-bound chaperonic proteins, which have also been shown to be present on the cell surface. Some of them have been found to be associated with lipid rafts, MHC class I, and cell-signaling molecules such as signal transducer and activator of transcription (STAT) proteins in certain viral infections. Since there is evidence suggesting that PDIs have a role in the virus entry to the cell, they obviously play an important role in virus-host interactions and viral pathogenesis. In this review, we discuss potential roles of PDIs in viral infections, in order to disclose new antiviral therapeutic targets.

Keywords: protein disulphide isomerase; virus; chaperone

Year: 2013, Volume: 57, Issue: 3	Page From: 293, Page To: 304
doi:10.4149/av_2013_03_293
Price: 28.80 €

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