Home Acta Virologica 2013 Acta Virologica Vol.57, No.3, p.293-304, 2013

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

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Acta Virologica Vol.57, No.3, p.293-304, 2013

Title: Potential roles of protein disulphide isomerase in viral infections

Abstract: Protein disulphide isomerase (PDI) family members are predominantly endoplasmic reticulum (ER)-bound chaperonic proteins, which have also been shown to be present on the cell surface. Some of them have been found to be associated with lipid rafts, MHC class I, and cell-signaling molecules such as signal transducer and activator of transcription (STAT) proteins in certain viral infections. Since there is evidence suggesting that PDIs have a role in the virus entry to the cell, they obviously play an important role in virus-host interactions and viral pathogenesis. In this review, we discuss potential roles of PDIs in viral infections, in order to disclose new antiviral therapeutic targets.

Keywords: protein disulphide isomerase; virus; chaperone
Year: 2013, Volume: 57, Issue: 3 Page From: 293, Page To: 304
Price: 28.80 €

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