Acta Virologica Vol.57, No.3, p.333-338, 2013

Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Acta Virologica Vol.57, No.3, p.333-338, 2013
Title: Effects of the Q223R mutation in the hemagglutinin (HA) of egg-adapted pandemic 2009 (H1N1) influenza A virus on virus growth and binding of HA to human- and avian-type cell receptors
Author: O. SUPTAWIWAT, W. JEAMTUA, CH. BOONARKART, A. KONGCHANAGUL, P. PUTHAWATHANA, P. AUEWARAKUL

Abstract: The 2009 swine-origin influenza A virus (H1N1) and its initial reassortant vaccine strains did not grow well in embryonated eggs. The glutamine to arginine mutation at the amino acid position 223 (Q223R) of the hemagglutinin (HA) gene is the major mutation previously found in egg-adapted 2009 H1N1 strains and shown to enhance viral growth in embryonated eggs. However, the effect of this mutation on the receptor-binding preference had not been directly demonstrated. In this study, the Q223R mutation was shown to change the viral HA binding preference from the human-type receptor, α2,6-linked sialic acid, to the avian-type receptor, α2,3-linked sialic acid; and to enhance the viral growth in embryonated eggs but not in cell culture.

Keywords: influenza A virus; hemagglutinin; mutation Q223R; cell receptors; sialic acid

Year: 2013, Volume: 57, Issue: 3	Page From: 333, Page To: 338
doi:10.4149/av_2013_03_333
Price: 14.40 €

Aepress.sk