Home Acta Virologica 2013 Acta Virologica Vol.57, No.3, p.339-345, 2013

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

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Acta Virologica Vol.57, No.3, p.339-345, 2013

Title: Primary cultures of murine neurons for studying herpes simplex virus 1 infection and its inhibition by antivirals
Author: J. CYMERYS, T. DZIECIĄTKOWSKI, A. GOLKE, A. SŁOŃSKA, A. MAJEWSKA, M. KRZYŻOWSKA, M. W. BAŃBURA

Abstract: Herpes simplex virus 1 (HSV-1) establishes life-long latency in peripheral neurons, where productive replication is suppressed. To study the specific relationship between the virus and peripheral neurons that would not be affected by other cells usually present in in vivo systems, we present an in vitro model system based on primary cultures of murine neurons. This model system can be used for characterization of various virus strains  and testing of cytotoxicity and inhibitory activity of acyclovir (ACV), cidofovir (CDV) and other antivirals.

Keywords: herpes simplex virus 1; human herpesvirus 1; murine neurons; primary culture; acyclovir; cidofovir; cytotoxity
Year: 2013, Volume: 57, Issue: 3 Page From: 339, Page To: 345
doi:10.4149/av_2013_03_339
Price: 16.80 €






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