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Neoplasma Vol.61, No.1, p.17-26, 2014 |
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Title: Screening differential expression of serum proteins in AFP-negative HBV-related hepatocellular carcinoma using iTRAQ –MALDI-MS/MS | ||
Author: X. He, Y. Wang, W. Zhang, H. Li, R. Luo, Y. Zhou, C. Li,M. Liao, H. Huang, X. Lv, Z. Xie, M. He | ||
Abstract: Hepatocellular carcinoma (HCC) is serious condition associated with a high morbidity and mortality. Therefore is an urgent need to develop novel noninvasive techniques for early diagnosis, particularly for patients with AFP-negative [AFP(-)] HCC. In this study, iTRAQ-MALDI-MS/MS was used to identify differentially expressed proteins in AFP(-) HBV-related HCC compared with non-cancerous hepatitis B virus (HBV) and healthy controls subjects. The expression levels of the GSN protein were down-regulated in AFP(-) HBV-related HCC subjects compared with healthy controls and the HBV group (p<0.01), consistent with the iTRAQ results.
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Keywords: HCC, AFP Negative, iTRAQ, GSN | ||
Published online: 20-Sep-2013 | ||
Year: 2014, Volume: 61, Issue: 1 | Page From: 17, Page To: 26 | |
doi:10.4149/neo_2014_001 |
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