Neoplasma Vol.61, No.1, p.27-34, 2014
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| Title: MicroRNA-191 correlates with poor prognosis of colorectal carcinoma
and plays multiple roles by targeting tissue inhibitor of metalloprotease 3 |
| Author: S. Qin, Y. Zhu, F. Ai, Y. Li, B. Bai, W. Yao, L. Dong |
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Abstract: MicroRNA-191 (miR-191) is reported to be overexpressed in colorectal carcinoma (CRC), but the role of miR-191 in CRC progress remained unclear. This study demonstrated that High miR-191 expression was associated with clinical stage, lymph node metastasis, liver metastasis and depth of tumor invasion. Kaplan-Meier analysis indicated that patients with high miR-191 expression had a poor overall survival. Moreover, multivariate analysis showed that miR-191 was an independent prognostic factor in patients with CRC. Furthermore, we found that tissue inhibitor of metalloprotease 3 (TIMP3) was a direct target of miR-191 in colorectal cancer SW620 cells. TIMP3 downregulation mediated by miR-191 activated matrix metalloproteinases (MMPs) and thus promoted invasiveness of cancer cells. Anti-miR-191 could attenuate the invasiveness, suppress proliferation and induce apoptosis by restoring TIMP3 expression. Our results suggested that miR-191 might be a potential diagnostic and therapeutic target in patients with colorectal cancer.
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| Keywords: microRNA-191; colorectal carcinoma; prognosis; tissue inhibitor of metalloprotease 3 |
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Published online: 19-Sep-2013
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| Year: 2014, Volume: 61, Issue: 1 |
Page From: 27, Page To: 34 |
doi:10.4149/neo_2014_005
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