General Physiology and Biophysics Vol.32, No.4, p.467-478, 2

General Physiology and Biophysics Vol.32, No.4, p.467-478, 2013

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
6 times per year

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General Physiology and Biophysics Vol.32, No.4, p.467-478, 2013
Title: Nuclear receptors – target molecules for isoflavones in cancer chemoprevention
Author: Lucia Bialešová, Július Brtko, Vladimír Lenko, Dana Macejová

Abstract: Breast cancer is the most occurring type of cancer among women. In Slovakia, there are yearly diagnosed about 1900 new cases of this disease. Breast cancer treatment is very expensive, psychic stressful and in some cases ineffective. Therefore, it is essential to search for new and/or alternative methods for breast cancer treatment, since nuclear receptors are considered to be a central goal for maximizing treatment opportunities in breast cancer. Among natural ligands for estrogen receptors (ERα and ERβ), which are member of nuclear receptors superfamily, belongs also isoflavones. These natural compounds have similar structure to main female hormon-17β estradiol. A rich source of isoflavones is soy and its products. Three aglycones form of isoflavones (genistein, daidzein, glycitein) are predominantly found in soybean and red clover. Among other important isoflavones belongs also biochanin A and formononetin.

Keywords: Isoflavones — Nuclear receptors — Breast cancer — Chemoprevention

Year: 2013, Volume: 32, Issue: 4	Page From: 467, Page To: 478
doi:10.4149/gpb_2013064
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