General Physiology and Biophysics Vol.32, No.4, p.517

General Physiology and Biophysics Vol.32, No.4, p.517–525, 2013

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
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General Physiology and Biophysics Vol.32, No.4, p.517–525, 2013
Title: Suppression of exaggerated neuronal oscillations by oxytocin in a rat model of Parkinson’s disease
Author: Oytun Erbas, Fatih Oltulu, Dilek Taskiran

Abstract: Increased oscillatory activity has been demonstrated in the basal ganglia of Parkinson’s disease (PD) patients. The aim of the present study was to evaluate the effects of oxytocin (OT) on local field potentials (LFPs) in a rotenone-induced rat model of PD. Adult male Sprague-Dawley rats were unilaterally injected with rotenone (3 µg/µl in DMSO) into the left substantia nigra pars compacta whereas vehicle group was received only DMSO. PD-developed rats were then administered either OT (160 µg/kg/day, i.p.) or saline for three weeks. Following treatment period, LFPs were recorded from the left striatum of freely moving rats and neuronal cell loss was evaluated by Nissl staining. We found significant increase in all frequency bands except delta in saline group when compared with vehicle (p

Keywords: Parkinson’s disease — Rotenone — EEG — Oxytocin

Year: 2013, Volume: 32, Issue: 4	Page From: 517, Page To: 525
doi:10.4149/gpb_2013055
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