Home 
General Physiology and Biophysics 2013 General Physiology and Biophysics Vol.32, No.4, p.535–543, 2013
General Physiology and Biophysics 2013 General Physiology and Biophysics Vol.32, No.4, p.535–543, 2013
Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
General Physiology and Biophysics Vol.32, No.4, p.535–543, 2013 |
||
| Title: Quercetin attenuates oxidative stress in the blood plasma of rats bearing DMBA-induced mammary cancer and treated with a combination of doxorubicin and docetaxel | ||
| Author: Sabina Tabaczar, Anna Pieniążek, Jan Czepas, Joanna Piasecka-Zelga, Krzysztof Gwoździński, Aneta Koceva-Chyła | ||
| Abstract: The development of side-effects during doxorubicin-docetaxel (DOX-DTX) chemotherapy is considered as related to generation of oxidative stress by DOX. The addition of docetaxel potentiates this effect. Thus, antioxidants are assumed as a promising remedy for neutralizing deteriorating effects of reactive oxygen species (ROS) in pathological conditions and polyphenolic antioxidants are suitable candidates for such a therapeutic approach. We evaluated the ability of quercetin to attenuate oxidative stress developed during the process of DMBA carcinogenesis and DOX-DTX chemotherapy in the blood plasma of rats bearing mammary tumors. We have found that quercetin significantly improved the plasma nonenzymatic antioxidant capacity (NEAC) and reduced lipid peroxidation, which suggest the beneficial effect of flavonoid. The inclusion of quercetin to the DOX-DTX chemotherapy was also advantageous. A considerable decrease of carbonyls and lipid peroxidation products (TBARS) and improvement of the endogenous antioxidant defense system (an increase of NEAC, thiols and SOD activity) were observed compared to rats treated with DOX-DTX chemotherapy. These results suggest that quercetin could protect blood plasma constituents against oxidative damage evoked by DOX and DTX. |
||
| Keywords: Flavonoid — Quercetin — Doxorubicin — Docetaxel — Chemotherapy— Oxidative stress | ||
| Year: 2013, Volume: 32, Issue: 4 | Page From: 535, Page To: 543 | |
| doi:10.4149/gpb_2013048 |
||
|
|
 download file |
|