Home Acta Virologica 2013 Acta Virologica Vol.57, No.4, p.389-396, 2013

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.57, No.4, p.389-396, 2013

Title: Hepatitis B virus-induced hepatocellular carcinoma: The role of the virus x protein
Author: M. MOTAVAF, S. SAFARI, M. SAFFARI JOURSHARI, S. M. ALAVIAN

Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignant diseases and has the fourth highest mortality rate worldwide. Chronic hepatitis B virus (HBV) infection has been identified as a major risk factor in HCC. Currently available evidence support a critical role of hepatitis B virus x (HBx) gene and protein in the pathogenesis of HBV-induced HCC. HBx protein is a multifunctional regulator that modulates cellular signal transduction pathways, transcriptional regulations, cell cycle progress, DNA repair, apoptosis, and genetic stability by interacting with different host factors. This review describes the current state of knowledge about the biological roles of this protein in the development of HCC.

Keywords: hepatitis B x protein; hepatitis B virus; hepatocellular carcinoma; apoptosis; nuclear excision repair; epigenetic modifications
Year: 2013, Volume: 57, Issue: 4 Page From: 389, Page To: 396
doi:10.4149/av_2013_04_389


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