Acta Virologica Vol.57, No.4, p.447-451, 2013

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ISSN 0001-723X
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Acta Virologica Vol.57, No.4, p.447-451, 2013
Title: Disruption of pocket protein dream complexes by E7 proteins of different types of human papillomaviruses
Author: N. NOR RASHID, R. YUSOF, R. J. WATSON

Abstract: It has been shown that the E7 protein of the high-risk HPV-16 transforms cells in vitro and binds pRB, p107 and p130, so called pocket proteins associated in cells with DREAM proteins, while that of the low-risk HPV-6 does not transform cells and binds p130 but not pRB or p107. These facts may indicate that p130 is essential for the HPV life cycle. To gain further insight into the relationship between HPV E7 proteins and pocket protein-DREAM complexes, E7 proteins of HPVs of various risk categories were expressed via appropriate vectors in T98G cells and the levels of various pocket proteins either total or associated with DREAM were analyzed. The obtained results demonstrated that high-risk HPV-16, HPV-18 and HPV-33, low-risk HPV-1 and HPV-11, and cutaneous HPV-48 disrupted pocket protein-DREAM complexes in T98G cells to a similar extent.

Keywords: human papillomavirus; E7 protein; pocket proteins; DREAM complex

Year: 2013, Volume: 57, Issue: 4	Page From: 447, Page To: 451
doi:10.4149/av_2013_04_447
Price: 12.00 €

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